Q: I’ve heard methotrexate is used for cancer. What else can it treat?
A: While methotrexate is indeed a chemotherapy drug, it’s also a versatile medication approved for several non-cancer conditions. Doctors often prescribe it "off-label" (for uses not originally approved) to manage autoimmune diseases and other inflammatory disorders.
Q: How does methotrexate work for non-cancer conditions?
A: Methotrexate calms an overactive immune system. In autoimmune diseases, the body mistakenly attacks healthy cells, causing inflammation. Methotrexate slows this process, reducing damage and symptoms like pain or swelling.
Q: What specific conditions can it help with?
Here’s a breakdown of common uses:
Rheumatoid Arthritis (RA): A top choice for RA, methotrexate eases joint pain, stiffness, and slows disease progression. It’s often paired with other medications.
Psoriasis & Psoriatic Arthritis: Reduces skin flare-ups (scaly patches) and joint inflammation linked to psoriasis.
Inflammatory Bowel Disease (IBD): Helps control Crohn’s disease and ulcerative colitis by calming gut inflammation, easing diarrhea, and preventing flares.
Ectopic Pregnancy: Used early to safely dissolve a pregnancy growing outside the uterus, avoiding surgery.
Q: Is it safe? What should I know about side effects?
A: Methotrexate is effective but requires careful monitoring. Common side effects include nausea, fatigue, or mouth sores. Rarely, it can affect liver or blood cells. Your doctor will order regular blood tests and may prescribe folic acid to reduce side effects.
Q: Can I take methotrexate if I’m pregnant or planning pregnancy?
A: No. Methotrexate can cause birth defects and must be avoided in pregnancy. If you’re planning a family, discuss timing with your doctor.
Q: How is it taken for non-cancer conditions?
A: Doses are much lower than for cancer. It’s often taken weekly as pills or injections. Never take it daily—this increases risks.
Key Takeaways:
Methotrexate is a multitasker: It treats cancer and chronic inflammatory diseases.
It’s not a quick fix—it may take weeks to notice improvement.
Always follow your doctor’s instructions and attend check-ups.
Talk to Your Healthcare Provider:
Methotrexate can be life-changing for conditions like RA or psoriasis, but it’s not right for everyone. Your doctor will weigh benefits against risks based on your health history. Never adjust your dose without consulting them!
